The story in the second season is a reboot of the first season but the main characters' names and roles are still similar to those in the first season. Some new characters and new subplots are also introduced in this season. In My Date with a Vampire II, Fong Kwok-wah and Yamamoto Ichifu clash again in 1938 and their fight arouses the attention of Cheung San (the progenitor of all vampires), who interrupts the fight. Just as Cheung San is about to bite the two men and turn them into vampires, Ma Dan-na appears and attacks Cheung San, driving him away, thus sparing Fong and Yamamoto from their fates. Not long later, Fong agrees to help Ma hunt down and destroy Cheung San. They succeed in trapping Cheung San but he breaks free and bites Fong and the boy Fuk-sang (who is nearby), transforming them into vampires. Fong Kwok-wah and Fuk-sang survive until the present-day (1990s) and their physical appearances have not changed since 60 years ago. However, before Fong became a vampire, he already had a son with his wife Sau, so he now has a grandson named Fong Tin-yau. Fong Tin-yau is killed in an incident in England so Fong Kwok-wah impersonates his grandson. He meets Ma Siu-ling (a descendant of Ma Dan-na), the heiress to a clan of ghostbusters who have dedicated themselves to ridding the world of evil supernatural beings. Fong starts a romance with Ma.